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In 2014, a paper in the *Journal of Pharmacology and Experimental Therapeutics* laid out dihexa's proposed mechanism that it works by binding hepatocyte growth factor and activating the c-Met system to build synapses

System xc is a cystine and glutamate antiporter responsible for the transportation of intracellular glutamate out of the cell and extracellular cystine into the cell at a 1:1 ratio (35)